Additional methods can increase the chances of successful treatment.
This is a special form of in vitro fertilization (IVF). In severe impairment of male fertility, the sperm is unable to fertilize the egg. In this case specific individual sperm cells are taken from the prepared sperm by use of a hollow needle and subsequently injected into a prepared mature egg.
In highly reduced semen, other criteria are applied to select quality individual spermatozoa for ICSI through an extremely time-consuming and technically complicated selection process. Fertilization is therefore also possible in cases where semen quality is extremely poor.
In cases where there is a complete absence of sperm in the semen, for example, vas deferens blockage or malfunction of semen production in the testes, sperm can be obtained by surgical procedure from the epididymis or testis.
In some cases, infertility is due also to the fact that the shell of the egg – and subsequently also embryonic shell – is thickened. Fertilization as a first step is made more difficult by means of ICSI), but also the second step, the "hatching" of the embryo, which must be done before implantation. In "assisted hatching" the shell of the embryo is thinned, selectively by laser, so that, when the time comes, the embryo can easily leave its shell.
The proper preparation of the endometrium for implantation is essential for the onset of pregnancy. In addition to hormonal factors, some contributing elements may also stem from the seminal fluid. A number of studies have shown that treatment of the endometrium with processed semen (seminal plasma rinse) often has a positive effect on pregnancy rates in IVF.
The term "embryo glue" also refers to an implantation aid. A special combination of substances which is added to the embryo transfer media, increases the embryo's ability to attach itself inside the uterine cavity. This process can significantly improve pregnancy rate, namely when special basic conditions are present.